Related Experiment Video
Updated: Feb 21, 2026
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
[Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of
A M Mendzheritski1, G V Karantysh1, V A Abramchuk1
1Pedagogical Institute of the South Federal University, Rostov-na-Donu, 344082, Russian Federation.
Abstract:
The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held. Regional changes in activity and the content of caspase-3 in the cerebral cortex and brainstem of young and old rats under the influence of peptides were identified. It is suggested that the functional state of caspase-3 in the brain is one of the reasons that determines the animals' ability to learn. Pinealon has prevalent positive effect on learning of both young and old animals in the Morris labyrinth compared to cortexin.
