Related Experiment Video
Updated: Feb 21, 2026

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
Published on: September 9, 2015
Predictive Performance of Vancomycin Trough Concentrations in Patients With Diabetes With Microalbuminuria
Hiroshi Kimura1, Marie Shigematsu, Akihiro Tanaka
1*Division of Pharmacy, Ehime University Hospital, Ehime, Japan; and †Department of Pharmaceutics, College of Pharmaceutical Sciences, Matsuyama University, Ehime, Japan.
Background:
The performance of a population pharmacokinetic model in predicting trough concentrations after the initial vancomycin dose was evaluated in patients with albuminuria compared with patients who did not have albuminuria.
Methods:
Data were collected from 52 patients infected with methicillin-resistant Staphylococcus aureus (excluding patients undergoing dialysis and acute kidney injury) and treated with vancomycin. The data included urinary albumin concentration.
Results:
The calculated mean prediction error and mean absolute error for the serum trough concentrations of vancomycin (with 95% confidence intervals) were 4.65 (4.13-5.17) and 6.1 (5.65-6.51), respectively, in microalbuminuria and 0.33 (-0.2 to 0.86) and 4.02 (3.59-4.45), respectively, in those without. There was no significant difference observed in serum creatinine concentration, age, weight, estimation of vancomycin trough concentration in serum, and actual trough concentration of vancomycin in serum between individuals with microalbuminuria and those without albuminuria.
Conclusions:
Microalbuminuria in patients with diabetes is a marker of the difference between predicted vancomycin trough concentrations and actual vancomycin trough concentrations.
Related Concept Videos
Estimation of k and VD of Aminoglycosides
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

