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Updated: Feb 21, 2026
Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts
Published on: August 23, 2017
Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential
Brigitta Matta-Domjan1, Alice King2, Stella Totti1
1Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
Abstract:
Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds-which are easily tuneable to form sheets/fibers-support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1637-1644, 2018.
