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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Related Experiment Video

Updated: Feb 21, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

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Hepatitis C and hepatocellular carcinoma.

Kunio Okuda1

  • 1Department of Medicine, Chiba University School of Medicine, Chiba, Japan.

Journal of Gastroenterology and Hepatology
|October 5, 2017
PubMed
Summary

Hepatitis C virus (HCV) infection is a major cause of liver cancer (hepatocellular carcinoma/HCC) globally, particularly in industrialized nations. Research compares HCV

Area of Science:

  • Hepatology and Viral Oncology

Background:

  • Hepatitis C virus (HCV) infection is a significant global health concern.
  • HCV is closely associated with the development of hepatocellular carcinoma (HCC).
  • Hepatitis B virus (HBV) is a predominant cause of HCC in developing countries, while HCV is more significant in industrialized nations.

Purpose of the Study:

  • To compare the etiological role of HCV infection in hepatocarcinogenesis across different countries.
  • To describe the progression of chronic hepatitis C to cirrhosis and HCC.
  • To discuss the reasons for the recent increase in HCV infection and HCC incidence.

Main Methods:

  • Comparative analysis of etiological roles of viral hepatitis.
  • Review of studies on the progression of chronic hepatitis C.
  • Discussion of epidemiological trends in HCV infection and HCC.
Keywords:
anti-hepatitis C virus antibodieshepatitis B virushepatitis C virushepatocellular carcinoma

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Main Results:

  • HCV plays a more critical role in hepatocarcinogenesis in industrialized countries compared to HBV.
  • Variations exist in the progression speed from chronic hepatitis C to cirrhosis and HCC among different populations.
  • Discrepancies noted between American and Japanese study experiences regarding HCV and HCC.

Conclusions:

  • HCV is a primary driver of liver cancer in industrialized nations.
  • The progression of HCV to HCC varies geographically.
  • The genetic mechanisms underlying HCV-induced hepatocarcinogenesis require further investigation.