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Clostridium difficile, sulphasalazine, and ulcerative colitis.

D A Burke1, A T Axon

  • 1Gastroenterology Unit, General Infirmary, Leeds, UK.

Postgraduate Medical Journal
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

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Clostridium difficile does not cause ulcerative colitis relapses and is not acquired during them unless antibiotics are used. Sulphasalazine does not increase the risk of Clostridium difficile infection in ulcerative colitis patients.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Ulcerative colitis (UC) relapse is sometimes linked to Clostridium difficile.
  • The role of C. difficile and its association with sulphasalazine in UC relapse remain debated.

Purpose of the Study:

  • To investigate the association between Clostridium difficile and ulcerative colitis relapse.
  • To determine if sulphasalazine influences C. difficile acquisition in UC patients.

Main Methods:

  • Investigated 77 patients with documented UC relapse for C. difficile presence or toxin before hospitalization.
  • Monitored C. difficile occurrence during treatment, noting antibiotic exposure.
  • Assessed sulphasalazine use in relation to C. difficile detection.

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Main Results:

  • Low incidence of C. difficile detection (2/62) in relapsed UC patients, linked to antibiotic exposure.
  • C. difficile occurrence during treatment (2/66) was also associated with antibiotic use.
  • No patients taking sulphasalazine tested positive for C. difficile or its toxin.

Conclusions:

  • Clostridium difficile is not causally related to ulcerative colitis relapse.
  • Secondary acquisition of C. difficile during relapse is primarily linked to antibiotic exposure, not UC itself.
  • Sulphasalazine does not predispose patients to C. difficile acquisition, and routine screening is unwarranted.