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Updated: Feb 21, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
A comprehensive scoring system to evaluate patient-centred risk factors regarding lower extremity amputation
M S Miller1, E W Newgent2, S M O'Connell3
1CEO and Medical Director, Assistant Professor, Miller Care Group, Indianapolis, IN, US; Marian University College of Osteopathic Medicine, Indianapolis, IN, US.
This study introduces the Miller-Newgent Amputation Scale (MENACE) to guide decisions for lower extremity amputation. MENACE prioritizes patient-centered factors for better outcomes, moving beyond purely medical considerations.
Area of Science:
- Podiatric medicine
- Surgical decision-making
- Patient-centered care
Background:
- Lower extremity wounds present complex challenges, often leading to amputation based on surgeon perception rather than patient-centered factors.
- Current decision-making for limb-threatening wounds may not adequately incorporate patient-centered considerations, potentially impacting long-term outcomes.
- Recurrence of wound issues after treatment can lead to further complications, including amputation.
Purpose of the Study:
- To review considerations and recommendations for lower extremity amputation, including short- and long-term implications.
- To address the need for objective criteria in amputation decision-making, incorporating patient-centered issues.
- To introduce the Miller-Newgent Amputation Scale (MENACE) as a tool for evaluating factors in lower extremity amputation.
Main Methods:
- Review of existing literature on lower extremity amputation considerations.
- Development of a set of patient-centered, verifiable criteria for amputation evaluation.
- Introduction of the Miller-Newgent Amputation Scale (MENACE) for decision support.
Main Results:
- Existing approaches to lower extremity amputation decisions are often based on healthcare professional perceptions.
- There is a significant need for a standardized, patient-centered approach to amputation decision-making.
- The proposed MENACE provides a framework to evaluate both medical and patient-centered issues.
Conclusions:
- The Miller-Newgent Amputation Scale (MENACE) aims to improve decision-making for lower extremity amputation.
- MENACE focuses on patient-centered issues to enhance short- and long-term physical and quality-of-life outcomes.
- Implementing MENACE can lead to more informed and patient-aligned amputation decisions.
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