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Clinical Laboratory Tests in Some Acute Exogenous Poisonings
Stoilka G Tufkova1, Ivan V Yankov2, Diana A Paskaleva3
1Second Department of Internal Diseases, Toxicology Section, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
Routine clinical laboratory tests can help assess vital functions in acute poisoning cases. Key indicators include red blood cells, hematocrit, hemoglobin, leukocytes, total protein, sodium, bilirubin, AST, and ALT levels.
Area of Science:
- Clinical Toxicology
- Laboratory Medicine
- Emergency Medicine
Background:
- Acute exogenous poisoning lacks specific toxicological screening of clinical laboratory parameters.
- Standardized assessment of vital functions in intoxicated patients is crucial.
Purpose of the Study:
- To identify routine clinical laboratory parameters for assessing vital functions in acute intoxication patients.
- To establish a model for selecting clinical laboratory tests in severe acute poisoning.
Main Methods:
- Study included 153 patients hospitalized for intoxication (medication, alcohol, heroin) and 35 controls.
- Standardized laboratory tests were performed.
- Statistical analyses included ANOVA and non-parametric tests.
Main Results:
- Statistically significant changes observed in red blood cells, hematocrit, hemoglobin, and leukocytes.
- Significant alterations in serum total protein, sodium, and bilirubin were noted.
- Elevated AST and ALT activities showed the highest statistical significance.
Conclusions:
- A model for selecting clinical laboratory tests for severe acute poisoning was developed.
- The studied clinical laboratory parameters can serve as a mandatory diagnostic element for moderate to severe intoxications.
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