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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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Cardiovascular risk and bipolar disorder: factors associated with a positive coronary calcium score in patients with

Aline R Wageck1,2, Felipe S Torres3,4, Clarissa S Gama1,2

  • 1Programa de Transtorno Bipolar, Laboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999)
|October 5, 2017
PubMed

Insights

Older age and more psychiatric hospitalizations are linked to higher coronary calcium scores (CCS) in bipolar disorder patients. This highlights the need for cardiovascular risk assessment in this population.

Area of Science:

  • Cardiology
  • Psychiatry
  • Medical Imaging

Background:

  • Cardiovascular disease (CVD) is the primary cause of mortality in individuals with bipolar disorder.
  • Assessing CVD risk factors in bipolar disorder patients is crucial for improving outcomes.

Purpose of the Study:

  • To identify factors associated with a positive coronary calcium score (CCS) in patients diagnosed with bipolar disorder type 1.
  • To evaluate the utility of CCS as a potential diagnostic and stratification tool for CVD in this population.

Main Methods:

  • Computed tomography (CT) scanning was used to measure coronary calcium scores (CCS) in patients with bipolar disorder.
  • Clinical and sociodemographic data were collected and compared between patients with positive (CCS > 0) and negative (CCS = 0) scores.
  • Poisson regression analysis examined the association between CCS and the number of psychiatric hospitalizations.

Main Results:

  • Out of 41 patients, 10 had a positive CCS.
  • Patients with positive CCS were significantly older (55.2 vs. 43.1 years) and had more psychiatric hospitalizations (4.7 vs. 2.6) compared to those with negative CCS.
  • A positive correlation was found between the number of psychiatric hospitalizations and CCS (p < 0.001).

Conclusions:

  • Older age and a higher number of psychiatric hospitalizations are significantly associated with increased CCS in bipolar disorder patients.
  • CCS may serve as a valuable tool for CVD risk assessment and stratification in individuals with bipolar disorder.
  • Increased awareness and proactive risk assessment for CVD are essential in the bipolar disorder patient population.
Abstract

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