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Temperament and character traits in major depressive disorder: a case control study
Barbara Schwair Nogueira1, Renerio Fraguas2, Isabela Martins Benseñor3
1MD, MSc, PhD. Psychologist, Hospital Universitário, Universidade de São Paulo (HU/USP), Center for Clinical and Epidemiological Research & Interdisciplinary Center for Applied Neuromodulation (Centro Interdisciplinar de Neuromodulação Aplicada, CINA), São Paulo (SP), Brazil.
Major depressive disorder (MDD) patients show distinct personality traits. Anxiety, not affect, fully explains the link between depression and harm avoidance personality traits.
Area of Science:
- Psychiatry
- Psychology
- Neuroscience
Background:
- Major depressive disorder (MDD) is associated with distinct personality traits.
- The influence of anxiety and affect on these personality differences is not well understood.
Purpose of the Study:
- To investigate personality trait differences between patients with MDD and controls.
- To determine the mediating role of anxiety and affect in the relationship between MDD and personality traits.
Main Methods:
- A case-control study involving 103 depressed patients and 103 controls.
- Utilized self-reported scales: Positive and Negative Affect Schedule (PANAS), State-Trait Anxiety Inventory (STAI), and Cloninger's Temperament and Character Inventory (TCI).
- Employed multivariate/bivariate analyses of variance (MANOVA/ANOVA) and mediation analyses.
Main Results:
- Depressed patients exhibited higher harm avoidance and lower self-directedness.
- Harm avoidance differences disappeared after adjusting for anxiety trait.
- Anxiety trait, not state-anxiety or affect, fully mediated the group's influence on harm avoidance.
Conclusions:
- Confirms distinct personality traits in MDD patients compared to controls.
- Suggests MDD is not directly linked to harm avoidance; this association is mediated by anxiety trait.
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