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GENOTOXICITY AND CYTOTOXICITY OF X-RAYS IN CHILDREN EXPOSED TO PANORAMIC RADIOGRAPHY

Evelyn Louise Antonio1, Aguinaldo José do Nascimento2, Antonio Adilson Soares de Lima2

  • 1Prefeitura Municipal de Curitiba, Curitiba, PR, Brasil.

Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo
|October 5, 2017
PubMed

Insights

Panoramic radiography X-rays may cause cell death in children's oral mucosa epithelium. However, this study found no significant genotoxic effects from the radiation exposure in pediatric patients.

Area of Science:

  • Oral medicine
  • Radiology
  • Cell biology

Background:

  • Panoramic radiography is a common dental imaging technique.
  • Ionizing radiation from X-rays can potentially cause cellular damage.

Purpose of the Study:

  • To evaluate genotoxicity and cytotoxicity in the oral mucosa epithelium of children following panoramic radiography.
  • To assess the impact of X-ray exposure on oral mucosal cells in pediatric patients.

Main Methods:

  • Oral mucosa cells were collected from 30 children (4-10 years) before and after panoramic radiography.
  • Cells were analyzed using modified Feulgen Rossenbeck staining for genotoxic and cytotoxic changes.
  • Specific markers like micronuclei, pyknosis, karyorrhexis, and karyolysis were quantified.

Main Results:

  • A significant increase in pyknosis, buds, and broken eggs was observed post-X-ray exposure (p<0.05).
  • No statistically significant differences were found concerning gender or other studied cellular changes.

Conclusions:

  • X-rays from panoramic radiography may induce cell death (cytotoxicity) in the oral mucosa epithelium of children.
  • The study found no significant evidence of genotoxic effects in the oral mucosa cells after exposure.
Abstract

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