Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Feb 21, 2026

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Published on: March 7, 2011

LATE-ONSET SELF-HEALING LANGERHANS CELL HISTIOCYTOSIS: REPORT OF A VERY RARE ENTITY.

Fatma Sule Afsar¹, Malik Ergin², Gulcihan Ozek²

¹Ataturk Research and Training Hospital, Esmirna, Turquia.

Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo

|October 5, 2017

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Characteristics, Management, and 30-Day Mortality Predictors in an 18-Year Pediatric Candidemia Cohort.

Journal of fungi (Basel, Switzerland)·2026

Same author

Jacquet Erosive Dermatitis in a Child with DOCK8 Mutation.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026

Same author

Real-world outcomes and safety of colistin therapy in children with multidrug-resistant gram-negative infections: a nine-year experience.

European journal of pediatrics·2026

Same author

Frequency, Characteristics, Management, and Outcomes of Posttransplant Lymphoproliferative Disorder After Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Multicenter Retrospective Study of the Turkish Pediatric BMT Study Group

Turkish journal of haematology : official journal of Turkish Society of Haematology·2026

Same author

Evaluation of Long-Term Late Side Effects in High-Risk Neuroblastoma Patients Undergoing Autologous Bone Marrow Transplantation.

Klinische Padiatrie·2026

Same author

Analysis of the risk factors associated with bloodstream infections caused by Candida parapsilosis in pediatric patients and the determinants of fluconazole non-susceptibility: a retrospective 15-year cohort study.

BMC infectious diseases·2026

Late-onset self-healing Langerhans cell histiocytosis (LCH) is a rare condition presenting with skin lesions that resolve spontaneously. This case highlights the importance of monitoring patients for systemic involvement to confirm the diagnosis retrospectively.

Area of Science:

Dermatology
Pediatrics
Pathology

Background:

Langerhans cell histiocytosis (LCH) is a rare clonal proliferation of Langerhans cells.
Self-healing LCH is a rare, self-limited variant typically presenting in neonates.
Late-onset LCH is exceptionally rare, with few reported cases.

Observation:

A 4.5-month-old infant presented with an erythematopurpuric eruption.
Skin biopsy confirmed isolated cutaneous Langerhans cell histiocytosis.
Lesions spontaneously regressed within months.

Findings:

The patient was retrospectively diagnosed with late-onset self-healing LCH.
Diagnosis was confirmed after four years of follow-up with no skin or systemic involvement.
Late-onset LCH can present with purpuric lesions beyond the neonatal period.

Related Experiment Videos

Last Updated: Feb 21, 2026

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Published on: March 7, 2011

Implications:

Late-onset self-healing LCH requires retrospective diagnosis after prolonged observation.
Purpuric lesions in infants may indicate LCH and warrant biopsy.
Regular monitoring for systemic involvement is crucial for patients diagnosed with cutaneous LCH.