Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Folding

Protein Folding

Protein Folding

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

Organization of Genes

Organization of Genes

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA as a Genetic Template

DNA as a Genetic Template

DNA Packaging

DNA Packaging

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CDIN1-Codanin-1 complex defective in congenital dyserythropoietic anaemia type I is an RNA nuclease.

Nature communications·2026

Same author

Dissecting polycomb complexes for enhanced fetal hemoglobin production.

Blood·2026

Same author

Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation.

Nature communications·2026

Same author

Dissecting polycomb complexes for enhanced fetal hemoglobin production.

bioRxiv : the preprint server for biology·2026

Same author

MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia.

Blood·2026

Same author

Deciphering <i>cis</i>-regulatory elements using REgulamentary.

Bioinformatics advances·2026

Same journal

Circulating MYOM3 fragments reflect disease severity and therapeutic efficacy in tubular aggregate myopathy and Stormorken syndrome.

Human molecular genetics·2026

Same journal

The FVB-nmd SMARD1 mouse presents with early respiratory deficits and pathology that significantly impact lifespan.

Human molecular genetics·2026

Same journal

Utrophin requires α-Syntrophin to maintain neuromuscular junction integrity in mdx mice.

Human molecular genetics·2026

Same journal

A novel gene ACTRT3 mutations induce sperm malformations and fertilization failure via Acrosomal ultrastructural defects.

Human molecular genetics·2026

Same journal

Nucleic acid-based therapeutic strategies for modulator-refractory cystic fibrosis-causing variants.

Human molecular genetics·2026

Same journal

Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

Human molecular genetics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 21, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Between form and function: the complexity of genome folding.

A Marieke Oudelaar¹, Lars L P Hanssen¹, Ross C Hardison²

¹MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK.

Human Molecular Genetics

|October 5, 2017

Summary

This summary is machine-generated.

Nuclear organization influences gene activity. DNA folding within the nucleus, particularly the alpha-globin gene cluster, reveals layers of genome organization that impact processes like transcription and replication.

More Related Videos

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Designing a Bio-responsive Robot from DNA Origami

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Related Experiment Videos

Last Updated: Feb 21, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Designing a Bio-responsive Robot from DNA Origami

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Area of Science:

Genomics
Molecular Biology
Cell Biology

Background:

Chromatin organization within the nucleus is not random.
The relationship between DNA folding, nuclear processes (transcription, replication), and function is a key research question.

Purpose of the Study:

To explore the layers of genome organization.
To understand how DNA folding influences nuclear processes and gene activity.
To use the alpha-globin gene cluster as a model system.

Main Methods:

Review of current research on genome organization.
Analysis of the alpha-globin gene cluster as a model.
Integration of data on DNA folding and gene activity.

Main Results:

Evidence suggests nuclear organization reflects nuclear processes and is also influenced by independent folding mechanisms.
The alpha-globin gene cluster model illustrates multi-scale genome organization.
Specific folding patterns correlate with gene activity.

Conclusions:

Nuclear organization and DNA folding play crucial roles in regulating gene activity.
Both intrinsic chromatin folding and its interplay with nuclear processes contribute to genome function.
Further research into genome architecture is essential for understanding gene regulation.