Association between TGFB1 genetic polymorphisms and chronic allograft dysfunction: a systematic review and...

Area of Science:

• Nephrology
• Immunogenetics
• Transplantation Science

Background:

• Chronic allograft dysfunction (CAD) is a significant complication following kidney transplantation.
• Transforming growth factor-β1 (TGF-β1) plays a role in the pathogenesis of CAD.
• Polymorphisms in the TGFB1 gene, specifically rs1800470 and rs1800471, are investigated for their potential association with CAD risk.

Purpose of the Study:

• To conduct a meta-analysis evaluating the association between TGFB1 gene polymorphisms (rs1800470 and rs1800471) and the risk of chronic allograft dysfunction (CAD) after kidney transplantation.
• To explore the relationship between TGFB1 haplotypes and CAD risk.

Main Methods:

• A systematic literature search was performed across multiple databases including MEDLINE, EMBASE, CENTRAL, CNKI, and WANFANG.
• Data from eligible studies were extracted and pooled using odds ratios (ORs) with 95% confidence intervals (CIs).
• Quality assessment and publication bias were evaluated for all included studies.

Main Results:

• Eight studies comprising 1038 subjects were included in the meta-analysis.
• A statistically significant association was found between TGFB1 haplotypes associated with "HIGH" TGF-β1 secretion and an increased risk of CAD (OR: 3.56, 95% CIs: 2.20, 5.78, P < 0.001).
• No significant association was observed between TGFB1 codon 10 or codon 25 polymorphisms and the risk of CAD across five genetic models.

Conclusions:

• The haplotype of TGFB1 codon 10/25 T/T G/G and T/C G/G genotypes, which are linked to increased TGF-β1 production, is associated with an elevated risk of CAD in kidney transplant recipients.
• Individual TGFB1 polymorphisms at codon 10 or codon 25 were not found to be significantly associated with the development of CAD.