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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Noncoding RNA in drug resistant sarcoma

Xiaoyang Li1,2, Jacson K Shen2, Francis J Hornicek2

  • 1Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Oncotarget
|October 6, 2017
PubMed

Insights

Drug resistance in sarcoma limits treatment success. This review explores how noncoding RNAs, like microRNAs and long noncoding RNAs, play a role in drug-resistant sarcoma and their future therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Sarcomas are malignant tumors originating from mesenchymal cells.
  • Current sarcoma treatments face challenges due to drug resistance, leading to plateaued survival rates.
  • Traditional research focused on protein-coding genes, but noncoding RNAs are emerging as key players.

Purpose of the Study:

  • To review the current understanding of noncoding RNAs in drug-resistant sarcoma.
  • To highlight the characteristics of noncoding RNAs and their regulated genes in this context.
  • To explore the therapeutic potential of noncoding RNAs for overcoming sarcoma drug resistance.

Main Methods:

  • Literature review of existing research on noncoding RNAs and sarcoma.
  • Analysis of studies investigating the role of microRNAs and long noncoding RNAs in drug resistance.
  • Synthesis of information on gene regulation by noncoding RNAs in sarcoma.

Main Results:

  • Noncoding RNAs, including microRNAs and long noncoding RNAs, are implicated in the development of drug resistance in sarcoma.
  • These noncoding RNAs regulate various genes that contribute to chemoresistance.
  • Understanding these mechanisms opens new avenues for therapeutic intervention.

Conclusions:

  • Noncoding RNAs represent a promising area for developing novel strategies to combat drug resistance in sarcoma.
  • Targeting noncoding RNAs could potentially reverse or overcome resistance to existing chemotherapies.
  • Further research into noncoding RNA biology is crucial for advancing sarcoma treatment.
Keywords:
drug resistancelong noncoding RNA (lncRNA)microRNA (miR)noncoding RNA (ncRNA)sarcoma

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