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Long non-coding RNAs associated with non-small cell lung cancer
Yuting Zhan1, Hongjing Zang1, Juan Feng1
1Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Oncotarget
|October 6, 2017
Summary
Long non-coding RNAs (lncRNAs) are emerging as key players in non-small cell lung cancer (NSCLC). This review explores their roles and impact on NSCLC treatment response, offering new therapeutic insights.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Non-small cell lung cancer (NSCLC) is the predominant cause of cancer mortality worldwide.
- Long non-coding RNAs (lncRNAs), RNA molecules exceeding 200 nucleotides, are increasingly recognized for their roles in cancer.
- Emerging evidence links lncRNAs to NSCLC pathogenesis and treatment response.
Purpose of the Study:
- To elucidate the diverse roles of lncRNAs in NSCLC.
- To investigate the influence of lncRNAs on patient responses to radiochemotherapy and molecular therapies.
- To provide a comprehensive overview of lncRNAs in NSCLC treatment.
Main Methods:
- Literature review of current research on lncRNAs in NSCLC.
- Analysis of studies investigating lncRNA functions in NSCLC development.
- Synthesis of evidence regarding lncRNA involvement in therapeutic outcomes.
Main Results:
- lncRNAs are implicated in various hallmarks of NSCLC, including proliferation, metastasis, and immune evasion.
- Specific lncRNAs have been identified as predictive biomarkers for radiochemotherapy and molecular therapy efficacy.
- Dysregulation of lncRNAs significantly impacts patient prognosis and treatment outcomes.
Conclusions:
- lncRNAs represent a promising area for novel NSCLC diagnostics and therapeutics.
- Understanding lncRNA mechanisms can lead to personalized treatment strategies for NSCLC patients.
- Further research into lncRNAs is crucial for advancing NSCLC management.
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