Sustained Improvement in Administration of the Hepatitis B Vaccine Birth Dose: A Quality Improvement Initiative
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Updated: Feb 21, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
Sheri L Nemerofsky1, Bolanle Akingboye1, Claudia Ferguson2
11 Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY.
Insights
Implementing quality improvement methods significantly boosted timely hepatitis B vaccine birth dose administration in newborns. This initiative improved vaccination rates within 12 hours of life and before hospital discharge, demonstrating sustainable positive outcomes.
Area of Science:
- Public Health
- Pediatrics
- Quality Improvement Science
Background:
- The New York State Department of Health mandates the hepatitis B vaccine birth dose within 12 hours of life (HOL) for all full-term infants.
- Current adherence rates to this recommendation require improvement to ensure timely infant protection against hepatitis B.
- Maternal hepatitis B status should not be a barrier to timely vaccine administration.
Purpose of the Study:
- To enhance the timeliness of hepatitis B vaccine birth dose administration within 12 HOL.
- To increase the overall percentage of infants receiving the hepatitis B vaccine before hospital discharge.
- To assess the sustainability of improvements achieved through quality improvement initiatives.
Main Methods:
- Utilized multiple Plan-Do-Study-Act (PDSA) cycles to drive process changes.
- Employed statistical process control charts with 3-sigma control limits to monitor vaccination rates.
- Adjusted control limits over time to reflect and sustain performance improvements.
Main Results:
- Vaccination rates within 12 HOL increased from 13% to over 65% within six months.
- Sustained improvements in timely vaccination (within 12 HOL) were observed for over one year.
- Vaccine administration prior to discharge rose from 94% to 98%.
Conclusions:
- Quality improvement methodologies can effectively and rapidly enhance adherence to newborn vaccination guidelines.
- The observed improvements in hepatitis B vaccine administration timeliness and completeness are sustainable.
- These findings support the widespread adoption of PDSA cycles in healthcare settings to improve public health recommendations.
Abstract:
The New York State Department of Health recommends the administration of the hepatitis B vaccine birth dose within 12 hours of life (HOL) for all full-term babies irrespective of maternal hepatitis B status. The primary and secondary aims of the project were to improve the timeliness of vaccine administration and increase the total number of infants vaccinated prior to discharge. Multiple Plan-Do-Study-Act cycles were performed. Statistical process charts of percentages of vaccination within 12 HOL and prior to discharge were constructed with 3-σ (data within 3 standard deviations from a mean) control limits. These control limits were adjusted after achieving significant improvements in performance over time. Administration within 12 HOL improved from 13% to ≥65% within 6 months, and has been sustained for >1 year. Vaccine administration prior to discharge increased from 94% to 98%. Quality improvement methods can rapidly improve adherence to newborn vaccine recommendations and these effects are sustainable.
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