Switching on BTK-One Domain at a Time
Related Experiment Video
Updated: Feb 21, 2026

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer
Published on: April 19, 2021
Christopher Agnew1, Natalia Jura2
1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Abstract:
BTK kinase activity is controlled by multiple inhibitory domains, whose coordinated mechanism of action is poorly understood. In this issue of Structure,Joseph et al. (2017) use solution-based approaches to characterize conformational changes associated with the binding of each inhibitory tether, revealing a multi-step activation process and a previously unknown C-terminal autoinhibitory latch.
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