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Normal pharmacological and morphometric parameters in the noradrenergic hyperinnervated mutant mouse, "tottering"
1Department of Anatomy, Medical College of Pennsylvania, Philadelphia 19129.
Cell and Tissue Research
|April 1, 1988
Summary
The "tottering" mouse mutation causes overproduction of locus coeruleus axons and norepinephrine. However, other neurotransmitter systems and target brain regions remain unaffected, indicating a direct genetic effect on axonal growth.
Area of Science:
- Neuroscience
- Genetics
- Pharmacology
Background:
- The
Purpose of the Study:
- To investigate the neurochemical and anatomical consequences of the
Main Methods:
- Pharmacological analysis of monoaminergic and cholinergic neurons
- Immunocytochemical staining for tyrosine hydroxylase, serotonin, and choline acetyltransferase
- Measurement of neurotransmitter content and enzyme activity
Main Results:
- The
Conclusions:
- The