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Abnormal hematopoiesis and hematopoietic stem cell niche
Keiyo Takubo1, Takayuki Morikawa1, Hiroshi Kobayashi1
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 6, 2017
Summary
Hematopoietic stem cells (HSCs) are normally quiescent but proliferate during stress. The bone marrow microenvironment, or niche, influences HSC function and is implicated in diseases like leukemia.
Area of Science:
- Hematology
- Stem Cell Biology
- Microenvironment Biology
Background:
- Hematopoietic stem cells (HSCs) maintain quiescence under steady-state conditions.
- HSCs proliferate and differentiate during infection or inflammation, influenced by their niche.
- The bone marrow niche plays a critical role in regulating hematopoiesis and is implicated in leukemogenesis.
Purpose of the Study:
- To review recent advances in understanding HSC and niche functions.
- To discuss regulatory mechanisms governing HSCs during homeostasis, stress, and disease.
Main Methods:
- Literature review of recent studies on HSC/niche interactions.
- Analysis of regulatory mechanisms in hematopoiesis.
Main Results:
- HSC behavior is dynamically regulated by the bone marrow niche.
- Niche alterations contribute to abnormal hematopoiesis and diseases like leukemia.
- Understanding HSC/niche interplay is crucial for managing hematological disorders.
Conclusions:
- The bone marrow niche is a key regulator of HSC function in health and disease.
- Further research into HSC/niche interactions can inform therapeutic strategies for hematological malignancies.
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