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Abnormal hematopoiesis and hematopoietic stem cell niche

Keiyo Takubo1, Takayuki Morikawa1, Hiroshi Kobayashi1

  • 1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 6, 2017
PubMed

During steady-state conditions, hematopoietic stem cells (HSCs) maintain a quiescent status in the cell cycle. Upon infection or inflammation, bone marrow HSCs begin proliferating and generating differentiated hematopoietic cells via multi-lineage differentiation and self-renewal; this effect is partially due to the alteration of their surrounding microenvironment or niche. In addition, recent studies have revealed that the bone marrow niche critically contributes to abnormal hematopoiesis, including leukemogenesis. In this review, we discuss the recent advances in our understanding of HSC/niche functions and the regulatory machineries employed during homeostasis, stress hematopoiesis, or disease conditions.

Keywords:
Hematopoietic stem cellLeukemogenesisStem cell nicheStress hematopoiesis

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