Jove
Visualize
Contact Us

Related Concept Videos

Erythropoiesis01:14

Erythropoiesis

6.2K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
6.2K
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

4.9K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
4.9K
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

6.3K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
6.3K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

10.3K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
10.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of cross-mixing tests in differentiating etiologies of prolonged aPTT: a single-center retrospective study.

International journal of hematology·2026
Same author

Anemia visits and clinical patterns after identification of low hemoglobin at health checkups among women of reproductive age in Japan: a real-world claims and health checkup data study (AWARD study).

Current medical research and opinion·2026
Same author

Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia.

Scientific reports·2026
Same author

Intervascular Large B-cell Lymphoma with Severe Anemia and a High-titer of Cold Agglutinin.

Internal medicine (Tokyo, Japan)·2025
Same author

Comparison of severe aplastic anaemia and lower risk hypoplastic myelodysplastic neoplasms: Critical role of megakaryocyte count in distinguishing aplastic anaemia from myelodysplastic neoplasms.

British journal of haematology·2025
Same author

Clustered peptide regulating the multivalent interaction between RANK and TRAF6 inhibits osteoclastogenesis by fine-tuning signals.

Communications biology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 21, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.5K

Progress in iron metabolism research.

Hiroshi Kawabata1

  • 1Department of Hematology and Immunology, Kanazawa Medical University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 6, 2017
PubMed
Summary

Strict control of body iron is vital to prevent organ damage. Hepcidin, regulated by various factors and molecules, is the central controller of iron homeostasis, impacting iron absorption and release.

Area of Science:

  • Biochemistry
  • Physiology
  • Genetics

Background:

  • Iron is essential for cellular functions but toxic in excess, necessitating strict systemic control.
  • Hepcidin, produced in the liver, is the primary regulator of iron homeostasis.
  • Dysregulation of iron metabolism is linked to various diseases, including hereditary hemochromatosis and anemia.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of systemic iron homeostasis.
  • To understand the role of hepcidin and associated molecules in iron metabolism.
  • To explore the genetic basis of iron overload and deficiency disorders.

Main Methods:

  • Review of molecular mechanisms involved in iron sensing and hepcidin regulation.
  • Analysis of genetic mutations associated with iron metabolism disorders.
Keywords:
ErythroferroneHepcidinHereditary hemochromatosisIron-refractory iron deficiency anemia

More Related Videos

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.6K
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
05:36

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism

Published on: February 23, 2024

989

Related Experiment Videos

Last Updated: Feb 21, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.5K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.6K
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
05:36

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism

Published on: February 23, 2024

989
  • Discussion of clinical implications in conditions like hereditary hemochromatosis and anemia.

    • Main Results:

    • Hepcidin expression is modulated by iron levels, inflammation, hypoxia, and erythropoiesis.
    • Key regulatory molecules include HFE, TFR2, HJV, erythroferrone, and TMPRSS6.
    • Mutations in genes like HFE, TFR2, HJV, HAMP, SLC40A1, and TMPRSS6 lead to specific iron disorders.
    • Chronic anemias requiring transfusions can cause iron overload, managed by iron chelation therapy.

    Conclusions:

    • Hepcidin is a crucial mediator of iron balance, controlling intestinal absorption and macrophage release via ferroportin.
    • Genetic defects in the iron regulatory pathway result in significant human diseases.
    • Understanding these pathways is critical for managing iron overload and deficiency conditions.