Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

4.8K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
4.8K
Cerebral Hemispheres01:05

Cerebral Hemispheres

2.6K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.6K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

5.2K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
5.2K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.5K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.5K
Types of Intermediate Filaments01:31

Types of Intermediate Filaments

5.0K
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
5.0K
Cytoplasm01:16

Cytoplasm

92.3K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
92.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of transplant-eligible patients with myelodysplastic syndrome with excess blasts registered in an observational study: The JALSG-CS11-MDS-SCT.

Annals of hematology·2023
Same author

A prospective, multicenter, observational study of ixazomib plus lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma in Japan.

Annals of hematology·2023
Same author

In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein.

Methods in molecular biology (Clifton, N.J.)·2023
Same author

Laparoscopic hepatectomy for hepatocellular carcinoma in patients with hemophilia A and B: a report of two cases.

Clinical journal of gastroenterology·2023
Same author

Dupilumab in a patient with severe asthma and glucocorticoid hypersensitivity: a case report.

The Journal of international medical research·2023
Same author

EML4-ALK Gene Mutation Detected with New NGS Lung Cancer Panel CDx Using Sputum Cytology in a Case of Advanced NSCLC.

Diagnostics (Basel, Switzerland)·2023

Related Experiment Video

Updated: Feb 21, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.9K

Recent topics in IMiDs and cereblon.

Takumi Ito1,2, Hiroshi Handa1

  • 1Department of Nanoparticle Translational Research, Tokyo Medical University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 6, 2017
PubMed
Summary

Immunomodulatory drugs (IMiDs) and cereblon modulators are novel anticancer compounds targeting Cereblon (CRBN). These compounds, including CC-885, induce targeted protein degradation, offering new therapeutic strategies for cancers like acute myeloid leukemia.

Keywords:
CereblonIMiDsTargeted protein degradationThalidomide

More Related Videos

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

5.0K
Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

4.9K

Related Experiment Videos

Last Updated: Feb 21, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.9K
Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

5.0K
Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

4.9K

Area of Science:

  • * Molecular Biology
  • * Oncology
  • * Pharmacology

Background:

  • * Immunomodulatory drugs (IMiDs), derived from thalidomide, are effective anticancer agents targeting Cereblon (CRBN).
  • * Lenalidomide and pomalidomide are FDA-approved IMiDs used for multiple myeloma.
  • * Cereblon (CRBN) functions as a substrate receptor for CRL4, a ubiquitin ligase complex crucial in protein degradation.

Purpose of the Study:

  • * To review recent advancements in Cereblon (CRBN) modulators and their therapeutic applications.
  • * To highlight novel CRBN-binding compounds and their mechanisms of action.
  • * To discuss the potential of targeted protein degradation via CRBN for cancer therapy.

Main Methods:

  • * Review of current literature on IMiDs, cereblon modulators, and targeted protein degradation.
  • * Analysis of structural data for CRBN-binding compounds like CC-885.
  • * Examination of studies employing linker-based approaches for CRBN-mediated protein degradation.

Main Results:

  • * Novel cereblon modulators (CC-122, CC-220, CC-885) are under clinical development for various diseases.
  • * CC-885 induces degradation of GSPT1, leading to antiproliferative effects in acute myeloid leukemia.
  • * Linker-based strategies have successfully degraded target proteins (BRD4, BCR-ABL) via CRL4CRBN.

Conclusions:

  • * Cereblon modulators represent a promising class of therapeutics with diverse applications.
  • * Targeted protein degradation via CRBN offers a versatile platform for drug development.
  • * Continued research into CRBN-binding compounds and degradation technologies holds significant therapeutic potential.