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Updated: Feb 21, 2026

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
Published on: August 11, 2021
Serotonergic Control of Metabolic Homeostasis
Steven C Wyler1, Caleb C Lord1, Syann Lee1
1Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical CenterDallas, TX, United States.
Abstract:
New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.
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