Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

15.3K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
15.3K
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

10.3K
10.3K
The Equilibrium Constant03:10

The Equilibrium Constant

57.6K
Consider the oxidation of sulfur dioxide:
57.6K
Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

5.1K
The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
For extracting a solute from an aqueous phase into an...
5.1K
Chemical Equilibria: Systematic Approach to Equilibrium Calculations01:21

Chemical Equilibria: Systematic Approach to Equilibrium Calculations

1.7K
Equilibrium calculations for systems involving multiple equilibria are often complex. For example, to calculate the solubility of a sparingly soluble salt in an aqueous solution in the presence of a common ion, one must consider all the equilibria in this solution. Calculations for these systems can be complicated and tedious, so a systematic approach with a series of steps is often helpful. The process is detailed below.
The first step is to identify all the chemical reactions involved, The...
1.7K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.3K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Reply.

Deutsches Arzteblatt international·2026
Same author

Interpretation of Pharmacometabolomics Results: Fingerprint of Drug Exposure or Confounder Effects? Insights from a Urinary Metabolomics Study with Voriconazole in Healthy Participants.

International journal of molecular sciences·2026
Same author

The phenotypic spectrum and genetic determinants of severe spinal muscular atrophy in individuals with a single <i>SMN2</i> copy: an international retrospective observational study.

EClinicalMedicine·2026
Same author

Urinary Metabolomics Predict Acute Kidney Injury in Very-Low-Birth-Weight Infants with Patent Ductus Arteriosus.

Biomolecules·2026
Same author

Confidence Intervals for Comparing Two Independent Folded Normals: A Case Study in Bunion Surgery.

Statistics in medicine·2026
Same author

Emulated Effects of Glucagon-Like Peptide 1 Receptor Agonist Therapy in the General Population.

Journal of the American College of Cardiology·2026

Related Experiment Video

Updated: Feb 21, 2026

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction
12:38

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction

Published on: February 15, 2018

20.8K

Estimating Disequilibrium Coefficients.

Maren Vens1, Andreas Ziegler2

  • 1Institut für Medizinische Biometrie und Epidemiologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, Hamburg, 20246, Germany. m.vens@uke.de.

Methods in Molecular Biology (Clifton, N.J.)
|October 6, 2017
PubMed
Summary
This summary is machine-generated.

Gametic phase disequilibrium measures allele associations within gametes. This chapter details methods for estimating linkage disequilibrium (LD), including genotype-based approaches that avoid haplotype bias.

Keywords:
Allelic linkage disequilibriumCoefficient of determinationComposite linkage disequilibriumGametic phase disequilibriumGenotypic linkage disequilibriumHaplotypeHardy–Weinberg equilibriumLDheatmapLewontin’s D′Linkage disequilibriumPLINKsnpStats

More Related Videos

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability
09:49

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability

Published on: April 2, 2015

11.1K
Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy
06:37

Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy

Published on: June 15, 2022

4.2K

Related Experiment Videos

Last Updated: Feb 21, 2026

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction
12:38

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction

Published on: February 15, 2018

20.8K
Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability
09:49

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability

Published on: April 2, 2015

11.1K
Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy
06:37

Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy

Published on: June 15, 2022

4.2K

Area of Science:

  • Population genetics
  • Statistical genetics

Background:

  • Gametic phase disequilibrium describes nonrandom allele association within gametes.
  • Linkage disequilibrium (LD) is a specific instance of nonrandom association between alleles at linked genetic loci.

Purpose of the Study:

  • To introduce key measures for estimating allelic and genotypic linkage disequilibrium.
  • To demonstrate the application of software packages for LD estimation.

Main Methods:

  • Review of established statistical measures for allelic LD.
  • Introduction of genotype-based LD measures that bypass haplotype estimation.
  • Illustration of LD estimation using relevant software tools.

Main Results:

  • Genotype-based LD measures offer an alternative to haplotype-dependent methods.
  • Software packages facilitate practical LD estimation in genetic studies.

Conclusions:

  • Understanding and estimating LD is crucial in population genetics.
  • Genotype-based methods provide a robust approach to LD analysis, simplifying estimation and reducing bias.