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Updated: Aug 14, 2026

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Published on: October 14, 2021
Frequent immunoglobulin G4 expression in a common variant of primary cutaneous marginal zone B-cell lymphoma
Jing Ru Sun1, Lin Nong2, Xiao Qing Liu1
1Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.
Abstract:
Immunoglobulin (Ig)G4 expression was recently observed in a proportion of primary cutaneous marginal zone B-cell lymphoma (PCMZL) with plasmacytic differentiation. IgG4-related disease is characterised by polyclonal lymphoplasmacytic infiltration with IgG4 expression, storiform fibrosis and obliterative phlebitis in histopathology. Here we report three cases of common variants of PCMZL with predominant and varied IgG4 expression, suggesting there is an underlying clonal progression between these two entities.
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