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Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

Dehydration Synthesis

Dehydration Synthesis

Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...

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Updated: Feb 21, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Peptide Bond Formations through Flow Chemistry.

¹School of Chemistry, Cardiff University, Park Place, main building, Cardiff, UK.

Chemical Biology & Drug Design

|October 6, 2017

Summary

This summary is machine-generated.

Flow chemistry enables rapid, automated synthesis of peptides and proteins. This approach accelerates peptide bond formation using activated intermediates and low reagent concentrations.

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Area of Science:

Biochemistry
Organic Chemistry
Chemical Engineering

Background:

Automated synthesis is crucial for producing peptides and proteins efficiently.
Traditional batch synthesis methods can be slow and require high reagent concentrations.

Purpose of the Study:

To explore the application of flow chemistry in accelerating peptide and protein synthesis.
To demonstrate the advantages of flow chemistry for peptide bond formation.

Main Methods:

Utilizing flow chemistry principles for rapid activation of intermediates.
Performing peptide coupling reactions at low reagent concentrations in a continuous flow system.

Main Results:

Demonstrated successful peptide bond formations using flow chemistry.
Highlighted the efficiency of activating intermediates in flow conditions.
Showcased advancements in automated peptide synthesis.

Conclusions:

Flow chemistry is a key technology for fast and automated peptide and protein synthesis.
The presented examples confirm the utility of flow chemistry in advancing peptide bond formation techniques.