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Related Experiment Video

Updated: Feb 21, 2026

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells
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[Structural retinal and optic nerve changes in patients with post-geniculate visual pathway damage].

N M Eliseeva1, N K Serova1, V P Erichev2

  • 1Burdenko Scientific Research Neurosurgery Institute, 16 4-ya Tverskaya-Yamskaya St., Moscow, Russian Federation, 125047.

Vestnik Oftalmologii
|October 6, 2017
PubMed
Summary

Retrograde trans-synaptic degeneration is possible in the visual pathway after damage. Optical coherence tomography (OCT) revealed ganglion cell complex thinning in patients with post-geniculate visual impairment.

Keywords:
homonymous hemianopiaoptical coherence tomographypost-geniculate visual pathwayretrograde trans-synaptic degeneration

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Neuro-ophthalmology

Background:

  • Acquired visual pathway damage can lead to neural degeneration.
  • Understanding the pattern of degeneration is crucial for patient management.

Purpose of the Study:

  • To investigate the possibility of retrograde trans-synaptic neural degeneration.
  • To assess visual pathway degeneration following post-geniculate damage.

Main Methods:

  • Examined 22 patients with homonymous hemianopia from acquired post-geniculate visual pathway damage.
  • Utilized RTVue-100 Fourier-domain optical coherence tomography (OCT) for measurements.
  • Assessed peripapillary retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC).

Main Results:

  • Binocular GCC thinning, ipsilateral to the lesion, was observed in 12 of 22 patients.
  • RNFL thickness decrease was noted in 9 patients, with topographic correlation in 2.
  • GCC thinning was more prevalent in cases with hemianopsia acquired over 6 months prior (p<0.0009).

Conclusions:

  • Trans-synaptic retrograde degeneration is possible in the post-geniculate visual pathway.
  • OCT assessment of GCC and RNFL supports the occurrence of this degeneration.
  • Findings highlight the impact of post-geniculate lesions on retinal neural structures.