[Action of doubled derivatives of glutamic acid on mollusk neurons]

Application of doubled derivatives of glutamic and evoked depolarization of the membrane of identified mollusk neurons, whereas glutamate elicited biphasic responses. The effect of these substances depended on the length of the chain (CH2)n between the residues of glutamic acid; it was maximal for n = 8. Changes in membrane conductance were shown to depend on the kind of stereo conformation of these residues. Hill's coefficient for tested compounds was about 0.75. It is suggested that the doubled derivatives of glutamic acid are agonists of glutamate D-receptors.