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Related Concept Videos

Mechanism of Angiogenesis01:10

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Related Experiment Video

Updated: Feb 21, 2026

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
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Modeling angiogenesis with micro- and nanotechnology.

Li-Jiun Chen1, Hirokazu Kaji

  • 1Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan. kaji@biomems.mech.tohoku.ac.jp.

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|October 6, 2017
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Summary

This review explores micro-/nanotechnology models for studying angiogenesis, covering both pathological conditions and tissue regeneration. It aims to bridge these areas for improved clinical applications in vascularization.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Angiogenesis is crucial for tissue growth, regeneration, and pathological processes like tumor formation.
  • Vascularization is essential for the success of engineered tissues (e.g., cardiac, bone) and host integration.
  • Current research addresses pathological angiogenesis and regenerative strategies for ischemic tissues and wound repair.

Purpose of the Study:

  • To review current micro-/nanotechnology-based models for studying angiogenesis.
  • To bridge the understanding of pathological and regenerative angiogenesis.
  • To provide insights for clinical applications in angiogenesis.

Main Methods:

  • Analysis of cellular and tissue-level interactions in pathological angiogenesis.
  • Scaffold-based and targeted delivery approaches for regenerative angiogenesis.
  • Development of advanced models mimicking the microenvironment and controlled agent release.

Main Results:

  • Micro-/nanotechnology enables sophisticated modeling of angiogenic processes.
  • Engineered constructs can serve as scaffolds and reservoirs for therapeutic agents.
  • Models recapitulate the microenvironment for studying angiogenesis.

Conclusions:

  • Micro-/nanotechnology offers powerful tools for modeling angiogenesis.
  • Bridging pathological and regenerative angiogenesis research can accelerate clinical translation.
  • Advanced models hold promise for improving vascularization strategies in various medical fields.