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Central mediators of the zymosan-induced febrile response

Amanda Leite Bastos-Pereira1, Daniel Fraga1, Arturo Alejandro Dreifuss1

  • 1.

Journal of Basic and Clinical Physiology and Pharmacology
|October 6, 2017
PubMed
Abstract

Insights

Zymosan-induced fever involves prostaglandins, substance P, endothelin-1, and endogenous opioids. These mediators are crucial for the febrile response, as shown by studies using specific inhibitors and antagonists in rats.

Area of Science:

  • Immunology
  • Neuroscience
  • Pharmacology

Background:

  • Zymosan, a fungal complex, activates inflammatory pathways via Toll-like receptors.
  • Zymosan is commonly used to induce fever in research models.
  • Central mediators of zymosan-induced fever are not fully understood.

Purpose of the Study:

  • To investigate the roles of prostaglandins, substance P, endothelin-1 (ET-1), and endogenous opioids (eOPs) in zymosan-induced fever.
  • To elucidate the central mechanisms underlying zymosan-induced febrile responses.

Main Methods:

  • Utilized male Wistar rats for experimental studies.
  • Administered inhibitors and antagonists for key mediators.
  • Measured febrile response following zymosan administration.

Main Results:

  • Nonselective and selective cyclooxygenase inhibitors reduced fever and prostaglandin E2 levels.
  • Receptor antagonists for neurokinin-1, ETB, and μ-opioid receptors attenuated fever.
  • μ-opioid receptor antagonist also reduced fever from intra-articular zymosan injection.

Conclusions:

  • Prostaglandins are key mediators in zymosan-induced fever.
  • Substance P, ET-1, and endogenous opioids also play central roles.
  • These findings identify critical pathways in zymosan-induced inflammatory responses.
Keywords:
endothelinfeveropioidprostaglandinsubstance Pzymosan

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