Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epithelial dysfunction and airway hyperreactivity in asthma.

R G Goldie1, L B Fernandes, P J Rigby

  • 1Department of Pharmacology, University of Western Australia, Perth, Nedlands.

Progress in Clinical and Biological Research
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The unit-Weibull distribution as an alternative to the Kumaraswamy distribution for the modeling of quantiles conditional on covariates.

Journal of applied statistics·2022
Same author

Comparing ultrastable lasers at 7 × 10<sup>-17</sup> fractional frequency instability through a 2220 km optical fibre network.

Nature communications·2022
Same author

Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018
Same author

Impaired airway epithelial cell responses from children with asthma to rhinoviral infection.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
Same author

The effect of different nebulizers with and without intermittent positive pressure breathing on the absorption and metabolism of salbutamol.

British journal of clinical pharmacology·2012
Same author

The clinical pharmacology of salmefamol.

British journal of clinical pharmacology·2012
Same journal

DNA homology and chromosome stability: a sensitive yeast genetic system for identifying double-stranded DNA damage.

Progress in clinical and biological research·2018
Same journal

Endotoxin and sepsis: molecular mechanisms of pathogenesis, host resistance, and therapy. Proceedings of the 4th Conference of the International Endotoxin Society. Nagoya, Japan, October 23-27, 1996.

Progress in clinical and biological research·1998
Same journal

The pathogenic role of LBP in gram-negative sepsis and septic shock.

Progress in clinical and biological research·1998
Same journal

The role of interleukin 6 in endotoxin-induced inflammatory responses.

Progress in clinical and biological research·1998
Same journal

Role of nitric oxide and reactive oxygen species in endotoxin shock.

Progress in clinical and biological research·1998
Same journal

Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells.

Progress in clinical and biological research·1998
See all related articles

The airway epithelium acts as a barrier, and its damage in asthma can lead to hyperreactivity. Impaired epithelial function and viral infections also contribute to airway obstruction and asthma symptoms.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • The central airway epithelium is crucial for limiting solute diffusion into airway walls.
  • Airway hyperreactivity in asthma may stem from epithelial barrier compromise.
  • Epithelial dysfunction and viral infections are implicated in asthma pathogenesis.

Purpose of the Study:

  • To explore the role of the airway epithelium in asthma pathophysiology.
  • To investigate mechanisms linking epithelial damage to airway hyperresponsiveness.
  • To understand the contribution of viral infections to asthma exacerbations.

Main Methods:

  • This study is a review of existing literature and concepts.
  • Analysis of the epithelial barrier function in relation to solute diffusion.
  • Examination of smooth muscle relaxant factors and beta-adrenoceptor function.

Related Experiment Videos

Main Results:

  • Epithelial barrier compromise increases solute access to sub-epithelial structures.
  • Impaired release of smooth muscle relaxants by the epithelium contributes to hyperresponsiveness.
  • Viral infections cause inflammation-induced epithelial damage and beta-adrenoceptor hypofunction, leading to bronchial obstruction.

Conclusions:

  • The airway epithelium is a key player in maintaining airway homeostasis and preventing hyperreactivity.
  • Epithelial barrier dysfunction and altered signaling contribute significantly to asthma.
  • Viral-induced airway inflammation and epithelial damage are critical factors in asthma exacerbations.