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Updated: Feb 21, 2026

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
Published on: February 21, 2015
[Application of array comparative genomic hybridization analysis for fetuses with growth anomalies]
Lin Wang1, Xiaobin Wang, Na Cai
1Center of Medical Genetics, Northwest Women and Children's Hospital, Xi'an, Shaanxi 710061, China. qiangrongshx@126.com.
Objective:
To explore the genetic etiology for fetuses featuring intrauterine growth anomalies using array-based comparative genomic hybridization (aCGH).
Methods:
Forty-nine fetuses were enrolled in this study. Genomic DNA of the abortive tissues was analyzed with aCGH.
Results:
Fourteen (28.6%) samples were found with chromosomal aberrations, which included 8 chromosomal aneuploidies and 6 micro-aberrations (4 with known clinical pathogenecity and 2 with unknown clinical significance).
Conclusion:
Numerical and structural chromosomal aberrations underlie a significant proportion of fetal growth anomalies. aCGH has provided an effective method for delineating their genetic cause.

