Contemporary Use of Oral Antithrombotic Agents: Focus on Dual and Triple Therapeutic Approaches

Area of Science:

• Cardiology
• Vascular Medicine
• Pharmacology

Background:

• Atherosclerotic cardiovascular disease (ASCVD) poses a significant global health challenge.
• Antithrombotic agents are crucial for managing ASCVD and preventing vascular events.
• Combination antithrombotic therapy is indicated for specific patient groups, necessitating careful risk-benefit assessment.

Purpose of the Study:

• To review the role of dual and triple antithrombotic therapies in patients with ASCVD.
• To evaluate current research, guidelines, and consensus statements on antithrombotic strategies.
• To provide practical considerations for clinicians managing complex ASCVD cases.

Main Methods:

• Literature review of relevant research studies.
• Analysis of national guidelines and consensus statements.
• Discussion of clinical scenarios and practical management considerations.

Main Results:

• Combination antithrombotic therapy requires balancing thrombotic risk reduction against bleeding risk.
• Optimal use of dual or triple antithrombotic therapy varies across different thrombotic disease states.
• Evidence-based recommendations and practical insights are synthesized for clinical application.

Conclusions:

• Effective management of ASCVD necessitates a nuanced approach to antithrombotic therapy.
• Clinicians must individualize treatment strategies, considering both efficacy and safety.
• This review offers a framework for optimizing antithrombotic use in ASCVD patients.