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Genetic variation associated with cardiovascular risk in autoimmune diseases

Pedro P Perrotti1,2, Adrià Aterido1,3, Antonio Fernández-Nebro4

  • 1Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.

Plos One
|October 6, 2017
PubMed

Insights

This study reveals specific genetic factors contributing to increased cardiovascular disease (CVD) risk in autoimmune diseases. Understanding these genetic patterns can help manage CVD in patients with autoimmune conditions.

Area of Science:

  • Genetics
  • Immunology
  • Cardiology

Background:

  • Autoimmune diseases are linked to higher rates of cardiovascular events.
  • The genetic underpinnings of this increased cardiovascular disease (CVD) risk are not fully understood.

Purpose of the Study:

  • To investigate the genetic basis of CVD risk in individuals with autoimmune diseases.
  • To identify shared and distinct genetic factors influencing CVD risk across multiple autoimmune conditions.

Main Methods:

  • Genome-wide genotyping data from 6,485 patients across six autoimmune diseases were analyzed.
  • Association tests were performed for established CVD risk loci and autoimmune disease susceptibility loci.
  • Cross-phenotype meta-analysis (CPMA) was employed to identify genetic patterns associated with CVD risk.

Main Results:

  • 17 established CVD risk loci were significantly associated with CVD in autoimmune cohorts.
  • Six autoimmune susceptibility loci were also associated with CVD risk.
  • Genome-wide CPMA identified 10 genetic clusters linked to CVD risk, with two enriched in TNFα and IFNγ cytokine pathways.

Conclusions:

  • Specific genetic variations contribute to the elevated CVD risk observed in autoimmune diseases.
  • Genetic overlap exists between autoimmune conditions and cardiovascular risk factors.
  • Findings support targeted genetic investigation for CVD prevention in autoimmune populations.

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