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Updated: Feb 21, 2026
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Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
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Muscle fatigue: general understanding and treatment
Jing-Jing Wan1, Zhen Qin1, Peng-Yuan Wang1
1Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China.
Experimental & Molecular Medicine
|October 7, 2017
Summary
Muscle fatigue, a common clinical issue, is the exercise-induced decline in force production. This review covers its mechanisms, evaluation, markers, and effective, non-specific treatments for better understanding and management.
Area of Science:
- Physiology
- Clinical Medicine
- Exercise Science
Background:
- Muscle fatigue is a frequent clinical complaint, impacting patient function.
- Understanding fatigue mechanisms is crucial for effective treatment strategies.
Purpose of the Study:
- To provide a comprehensive overview of muscle fatigue.
- To discuss diagnostic markers and therapeutic interventions for muscle fatigue.
Main Methods:
- Literature review of studies on muscle fatigue.
- Analysis of force production events, in vivo evaluation techniques, and diagnostic markers.
- Summary of non-specific but effective treatment options.
Main Results:
- Detailed explanation of the sequence of events during force production.
- Overview of in vivo techniques for evaluating fatigue sites.
- Identification of key diagnostic markers and effective treatments.
Conclusions:
- Muscle fatigue is characterized by decreased force production following exercise.
- Effective management involves understanding its mechanisms, utilizing diagnostic tools, and applying appropriate therapies.
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