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Related Concept Videos

Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.3K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Related Experiment Video

Updated: Feb 21, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Targeting MicroRNA Function in Acute Pancreatitis.

Hong Xiang1,2, Xufeng Tao3, Shilin Xia4

  • 1College of Integrative Medicine, Dalian Medical UniversityDalian, China.

Frontiers in Physiology
|October 7, 2017
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) offer new insights into acute pancreatitis (AP) pathogenesis. Research highlights their role in AP development and potential for targeted therapies and biomarkers.

Keywords:
acute pancreatitisbiomarkermicroRNAtarget genetherapeutic tool

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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Related Experiment Videos

Last Updated: Feb 21, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Area of Science:

  • Gastroenterology and Molecular Biology
  • Focuses on the molecular mechanisms of gastrointestinal diseases.

Background:

  • Acute pancreatitis (AP) is a prevalent gastrointestinal disorder with increasing incidence and high mortality.
  • Current treatments for AP are limited due to incomplete understanding of its pathogenesis.
  • MicroRNAs (miRNAs) have emerged as key regulators in various biological processes, including inflammation.

Purpose of the Study:

  • To review the current understanding of miRNA involvement in acute pancreatitis.
  • To explore the potential of miRNA-based diagnostics and therapeutics for AP.

Main Methods:

  • Literature review of studies investigating miRNAs in AP.
  • Analysis of miRNA expression patterns and their functional roles in AP pathogenesis.
  • Evaluation of current and future applications of miRNAs in AP management.

Main Results:

  • Specific miRNAs are implicated in the cellular and inflammatory processes underlying AP.
  • Dysregulation of miRNA expression or mutations can contribute to AP development.
  • miRNAs show promise as biomarkers for AP diagnosis and as targets for novel therapies.

Conclusions:

  • miRNAs represent a significant area of research for understanding AP.
  • Targeted miRNA therapies offer a potential new frontier for AP treatment.
  • Further research into miRNAs could lead to improved diagnostic tools and therapeutic strategies for AP.