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Cross-hierarchy systems principles.

Lea Goentoro1

  • 1California Institute of Technology.

Current Opinion in Systems Biology
|October 7, 2017
PubMed
Summary

Systems biology seeks general design principles for biological systems. This work explores cross-hierarchy similarities as a source of these principles, presenting future research challenges.

Area of Science:

  • Systems Biology
  • Theoretical Biology
  • Biophysics

Background:

  • Systems biology aims to uncover fundamental principles governing biological system design.
  • Engineering concepts like robustness and modularity are increasingly applied to biological systems.
  • Emerging similarities across biological hierarchies offer another avenue for discovering general principles.

Purpose of the Study:

  • To explore potential general principles in biological system design.
  • To identify and describe emerging similarities in processes across different biological hierarchies.
  • To highlight future research directions in systems biology concerning cross-hierarchy principles.

Main Methods:

  • Conceptual analysis of existing biological system properties.

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  • Review and synthesis of emerging cross-hierarchy similarities.
  • Identification of potential general principles derived from these similarities.
  • Main Results:

    • Several emerging similarities in biological processes across different hierarchical levels have been identified.
    • These cross-hierarchy similarities suggest potential unifying principles in biology.
    • The convergence of principles across hierarchies presents significant challenges and opportunities for systems biology.

    Conclusions:

    • Cross-hierarchy similarities are a promising source for general principles in systems biology.
    • Understanding these convergent principles is crucial for comprehending biological system construction.
    • Further research into these principles will drive future advancements in systems biology.