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CD2 is involved in regulating cyclic AMP levels in T cells
A C Carrera1, M Rincón, M O De Landázuri
1Seccion de Immunología, Hospital de la Princesa, Madrid, Spain.
European Journal of Immunology
|June 1, 1988
Abstract:
The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP comparable to that induced by reagents which activate adenylate cyclase. These results indicate that there is a relationship between the CD2 membrane molecule and the adenylate cyclase system.