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Recruiting a representative sample in adherence research-The MALT multisite prospective cohort study experience.

Eyal Shemesh1, Jeffrey Mitchell2, Katie Neighbors3

  • 1Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Pediatric Transplantation
|October 7, 2017
PubMed
Summary

Recruiting non-adherent patients for transplant research is challenging. The MALT study successfully enrolled a representative sample of pediatric liver transplant recipients, crucial for accurate medication adherence research.

Keywords:
adherencepediatricrecruitmenttransplant

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Area of Science:

  • Transplant medicine
  • Clinical research methodology
  • Pediatric gastroenterology

Background:

  • Medication adherence significantly impacts transplant outcomes.
  • Research on adherence is often biased due to difficulties in recruiting non-adherent patients.
  • Selection bias can compromise the validity of adherence studies.

Purpose of the Study:

  • To describe recruitment strategies and results from the Medication Adherence in children who had a Liver Transplant (MALT) study.
  • To ensure a representative sample of pediatric liver transplant patients was recruited.
  • To assess the feasibility of recruiting and retaining participants for long-term adherence research.

Main Methods:

  • The MALT study prospectively followed 400 pediatric liver transplant patients for two years.
  • Recruitment strategies focused on minimizing patient burden and employing specific outreach methods.
  • Sample representativeness was evaluated by comparing the MALT cohort to a national sample of transplant recipients.

Main Results:

  • The MALT study successfully recruited a nationally representative sample of 400 pediatric liver transplant patients.
  • Key strategies included outcome monitoring against national data, reduced patient burden, and targeted recruitment.
  • The recruitment methods ensured the sample reflected the broader population of pediatric liver transplant recipients.

Conclusions:

  • Achieving a representative sample is critical for reliable medication adherence research in transplant populations.
  • The MALT study demonstrates effective strategies for recruiting and retaining diverse patient groups.
  • Future adherence research should prioritize robust recruitment methods to mitigate selection bias and enhance generalizability.