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[Glaphenine biliary lithiasis. Identification by infrared spectrophotometry]
C Moesch1, A Gainant, D Sautereau
1Laboratoire de Chimie organique pharmaceutique, UFR de Pharmacie, Limoges.
Gastroenterologie Clinique Et Biologique
|April 1, 1988
Summary
This study details a rare case of drug-induced choledocholithiasis caused by glafenic acid. Researchers identified the drug and its metabolites, marking the first reported instance of this condition.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
- Analytical Chemistry
Background:
- Choledocholithiasis, the presence of gallstones in the common bile duct, is typically associated with cholesterol or bilirubin stones.
- Drug-induced choledocholithiasis is an uncommon etiology, with limited documented cases.
Observation:
- A case of a woman presenting with choledocholithiasis is described.
- The bile duct stones were found to be primarily composed of glafenic acid.
Findings:
- Glafenic acid and its metabolites were unequivocally identified in the bile duct stones.
- Infrared spectrophotometry and thin-layer chromatography were employed for precise drug identification.
Implications:
- This case highlights glafenic acid as a potential cause of choledocholithiasis.
- Further research into drug-induced gallstone formation is warranted.
- Clinicians should consider drug etiology in unexplained choledocholithiasis cases.