ScaPD: a database for human scaffold proteins

Area of Science:

• Molecular Biology
• Cellular Biology
• Bioinformatics

Background:

• Scaffold proteins are crucial for biological signaling pathways, influencing selectivity and cellular behavior.
• Existing databases primarily focus on signaling pathways, with limited resources for scaffold proteins.
• Scaffold proteins mediate signal transduction, yet their comprehensive documentation is lacking.

Purpose of the Study:

• To develop a user-friendly database, ScaPD, for scaffold proteins and associated signaling pathways.
• To provide a centralized resource for computationally predicted and experimentally validated scaffold protein data.
• To facilitate research into scaffold protein function in signal transduction.

Main Methods:

• Computational prediction of scaffold proteins.
• Experimental validation of identified scaffold proteins.
• Database development for data storage, retrieval, and analysis.

Main Results:

• ScaPD database currently contains 273 scaffold proteins and 1118 associated signaling pathways.
• The database enables users to search, navigate, and download scaffold protein-mediated signaling networks.
• Data includes both computationally predicted and experimentally validated scaffold proteins.

Conclusions:

• ScaPD provides a foundational resource for scaffold protein research in signal transduction.
• The database will be continuously updated to maintain current data.
• ScaPD is a valuable resource for understanding the regulation of individual signaling pathways.