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ScaPD: a database for human scaffold proteins.

Xiaomei Han1,2, Jenny Wang3, Jie Wang2

  • 1Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

BMC Bioinformatics
|October 7, 2017
PubMed
Summary

ScaPD is a new database for scaffold proteins and their signaling pathways. It offers a valuable resource for researchers studying signal transduction and cellular regulation.

Keywords:
DatabaseScaffold proteinSignaling pathway

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Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Bioinformatics

Background:

  • Scaffold proteins are crucial for biological signaling pathways, influencing selectivity and cellular behavior.
  • Existing databases primarily focus on signaling pathways, with limited resources for scaffold proteins.
  • Scaffold proteins mediate signal transduction, yet their comprehensive documentation is lacking.

Purpose of the Study:

  • To develop a user-friendly database, ScaPD, for scaffold proteins and associated signaling pathways.
  • To provide a centralized resource for computationally predicted and experimentally validated scaffold protein data.
  • To facilitate research into scaffold protein function in signal transduction.

Main Methods:

  • Computational prediction of scaffold proteins.
  • Experimental validation of identified scaffold proteins.
  • Database development for data storage, retrieval, and analysis.

Main Results:

  • ScaPD database currently contains 273 scaffold proteins and 1118 associated signaling pathways.
  • The database enables users to search, navigate, and download scaffold protein-mediated signaling networks.
  • Data includes both computationally predicted and experimentally validated scaffold proteins.

Conclusions:

  • ScaPD provides a foundational resource for scaffold protein research in signal transduction.
  • The database will be continuously updated to maintain current data.
  • ScaPD is a valuable resource for understanding the regulation of individual signaling pathways.