Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety
Supojjanee Sansook1, Cory A Ocasio1, Iain J Day1
1Dept of Chemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QJ, UK. j.spencer@sussex.ac.uk.
Organic & Biomolecular Chemistry
|October 7, 2017
Abstract:
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
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