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Memory Complaints and Cognitive Decline: Data from the GUIDAGE Study1
Sophie Dardenne1,2, Julien Delrieu1,3, Sandrine Sourdet1,3
1Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Journal of Alzheimer'S Disease : JAD
|October 7, 2017
Summary
Subjective cognitive decline (SCD) can indicate future memory loss. The McNair and Kahn Scale effectively predicts cognitive decline, with a shorter 5-item version suitable for clinical screening.
Area of Science:
- Neurology
- Gerontology
- Cognitive Science
Background:
- Subjective cognitive decline (SCD) may signal early Alzheimer's disease (AD).
- Memory complaints assessed via the McNair and Kahn Scale in the GuidAge study.
- Cognitive decline can occur in cognitively normal individuals reporting SCD.
Purpose of the Study:
- To determine if the McNair and Kahn Scale predicts cognitive decline.
- To identify specific questions within the scale that best predict cognitive decline.
Main Methods:
- Utilized data from the phase III, multicenter, randomized GuidAge study.
- Included 1,307 individuals aged 70+ with SCD and no cognitive impairment (CDR=0).
- Assessed SCD using the 20-item McNair and Kahn Scale and cognitive status via standardized neuropsychological tests over 5 years.
Main Results:
- A significant association was found between McNair and Kahn Scale scores and cognitive decline (HR 1.012, p=0.0156).
- Over 5 years, 519 patients (39.7%) experienced cognitive decline.
- Five specific items from the 20-item scale were identified as statistically significant predictors of cognitive decline.
Conclusions:
- Subjective cognitive decline is a valuable indicator of potential memory impairment.
- The McNair and Kahn Scale demonstrates predictive value for cognitive decline.
- A concise 5-item version of the scale could be implemented for patient screening in clinical settings and research.
Keywords:
Alzheimer’s diseasecognitive declinememory complaintpreclinical stagesubjective cognitive complaintMore Related Videos
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