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Coronary artery-positive remodeling in current smokers
Anas Alani1, Yanting Luo2, Rine Nakanishim2
1Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.
Coronary Artery Disease
|October 7, 2017
Summary
Current cigarette smoking is independently linked to coronary artery-positive remodeling (CAPR), a finding on cardiac computed tomography angiography (CCTA). Current smokers face a 3.5-fold increased risk of developing CAPR.
Area of Science:
- Cardiology
- Radiology
- Public Health
Background:
- Coronary artery-positive remodeling (CAPR) is a plaque characteristic identified on cardiac computed tomography angiography (CCTA).
- The association between CAPR and cigarette smoking requires further investigation.
Purpose of the Study:
- To evaluate the association between coronary artery-positive remodeling (CAPR) detected by CCTA and cigarette smoking status.
Main Methods:
- A retrospective case-control study included 178 patients with CAPR plaque and 180 controls without positive remodeling.
- CAPR was defined as a 10% larger vessel diameter at the plaque site compared to a normal segment on CCTA images.
Main Results:
- Current smokers showed a significantly higher prevalence of CAPR (15.7%) compared to nonsmokers (57.9%) in the case group versus control group (6.1%).
- Logistic regression revealed a significant correlation between current smoking and CAPR, even after adjusting for risk factors.
- Current smokers had a 3.5-fold increased risk of CAPR compared to nonsmokers.
Conclusions:
- Cigarette smoking is independently associated with coronary artery-positive remodeling (CAPR) identified via CCTA.
- Current cigarette smokers exhibit a significantly elevated risk of developing CAPR.
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