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Cholangitis Lenta: A Clinicopathologic Study of 28 Cases
Vanda F Torous1, A Laura De La Cruz, Bita V Naini
1*Department of Pathology and Laboratory Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA †Department of Pathology and Laboratory Medicine, Rideout Memorial Hospital, Marysville ‡Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA.
Cholangitis lenta, a rare liver condition, is strongly linked to sepsis and high mortality rates, especially in liver transplant recipients. Prompt diagnosis via liver biopsy is crucial for immediate medical intervention.
Area of Science:
- Hepatology
- Gastroenterology
- Transplant Medicine
Background:
- Cholangitis lenta, also known as ductular cholestasis, is an uncommon cholangitis subtype.
- Limited studies exist, often suggesting links to sepsis or intra-abdominal infections.
Purpose of the Study:
- To investigate the clinical, laboratory, and histologic features of cholangitis lenta.
- To determine the association with sepsis and patient outcomes.
Main Methods:
- Retrospective analysis of 28 patients with cholangitis lenta.
- Review of clinical data, laboratory results, microbiology cultures, and liver biopsy findings.
Main Results:
- 89.3% of patients were liver transplant recipients.
- 85.7% had sepsis with positive microbiology cultures.
- 53.6% died during hospitalization; overall survival was 32.1%.
Conclusions:
- Cholangitis lenta is frequently associated with sepsis and carries a high mortality rate.
- Accurate liver biopsy diagnosis is imperative for identifying this life-threatening condition.
- Immediate medical attention and management are required upon diagnosis.
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