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HIV-related cardiovascular disease: closing the gap in mortality

Cameron J Holloway1, Franck Boccara

  • 1aSt Vincent's Hospital Sydney bUniversity of New South Wales, Sydney, New South Wales, Australia cAP-HP, Hôpitaux de l'Est Parisien, Hôpital Saint-Antoine, Service de Cardiologie dFaculty of Medicine, Sorbonne Universities, UPMC Sorbonne University Paris 06 eFrench National Institute of Health and Medical Research, INSERM, UMR_S 938, UPMC, Paris, France.

Current Opinion in HIV and AIDS
|October 7, 2017
PubMed

Insights

Human immunodeficiency virus (HIV) infection contributes to cardiovascular diseases (CVDs) through viral factors, antiviral therapy side effects, and inflammation. Managing these factors improves longevity, and insights from other systemic diseases may enhance CVD care for people living with HIV (PLHIV).

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • Chronic human immunodeficiency virus (HIV) infection is linked to cardiovascular diseases (CVDs).
  • Pathogenesis involves viral factors, metabolic derangements from antiviral therapy, and chronic systemic inflammation.
  • These factors contribute significantly to the development of CVD in people living with HIV (PLHIV).

Purpose of the Study:

  • To review the complex causes of HIV-related CVD.
  • To explore shared pathophysiological mechanisms between HIV and other chronic systemic diseases.
  • To identify potential improvements in CVD risk management for PLHIV.

Main Methods:

  • Review of existing literature on HIV, CVD, and systemic diseases.
  • Analysis of etiological factors in HIV-related cardiovascular complications.
  • Comparative analysis of pathophysiological pathways across different chronic conditions.

Main Results:

  • HIV-related CVD is driven by a combination of viral, therapeutic, and inflammatory factors.
  • HIV shares common pathogenic pathways with systemic diseases like diabetes and rheumatoid arthritis.
  • Current management strategies have improved outcomes for PLHIV.

Conclusions:

  • HIV-related CVD management may benefit from strategies used for other chronic systemic diseases.
  • Understanding shared mechanisms can lead to novel treatment concepts.
  • Optimizing CVD risk management in PLHIV requires integrating knowledge from broader systemic disease research.

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