Renal lineage cells as a source for renal regeneration

Related Experiment Video

Updated: Feb 21, 2026

Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration
07:27

Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration

Published on: August 29, 2011

15.8K

Oren Pleniceanu1, Dorit Omer1, Orit Harari-Steinberg1

  • 1Pediatric Stem Cell Research Institute and Division of Pediatric Nephrology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Pediatric Research
|October 7, 2017
PubMed

Insights

Researchers are exploring cell-based therapies to regenerate damaged nephrons in the kidney, offering new hope for chronic kidney disease (CKD) patients. Advances in stem cell technology and regenerative medicine are paving the way for viable kidney stem cell therapies.

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Developmental Biology

Background:

  • Chronic kidney disease (CKD) presents a growing global health challenge.
  • The mammalian kidney's complexity and limited self-repair capacity necessitate novel therapeutic strategies.
  • Recent advancements in understanding nephrogenesis offer new avenues for kidney regeneration.

Purpose of the Study:

  • To review cell-based therapeutic strategies for regenerating damaged nephrons.
  • To discuss the potential of various stem cell sources for kidney repair.
  • To highlight the progress toward viable kidney stem cell-based therapies for CKD.

Main Methods:

  • Review of current research on nephrogenesis and adult kidney cell origins.
  • Discussion of strategies including fetal kidney grafts, stem cell differentiation, adult progenitor isolation, and cell reprogramming.
  • Exploration of 3D culture techniques to mimic developmental environments.

Main Results:

  • Extrarenal cells, like bone marrow-derived cells, lack renal differentiation capacity.
  • Multiple cell-based approaches show promise for replenishing damaged renal parenchyma.
  • Integration of developmental biology techniques enhances regenerative potential.

Conclusions:

  • Cell-based therapies hold significant promise for treating chronic kidney disease.
  • Reliance on renal lineage cells is crucial for successful kidney regeneration.
  • Emerging techniques are bringing kidney stem cell therapy closer to clinical application.

More Related Videos

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

16.6K
A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells09:05

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells

Published on: August 7, 2017

7.4K

Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.2K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.5K
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.2K
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
4.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K