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3D bioprinting using stem cells.

Chin Siang Ong1, Pooja Yesantharao1, Chen Yu Huang2

  • 1Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, MD.

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|October 7, 2017
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Summary
This summary is machine-generated.

Three-dimensional bioprinting utilizes stem cells for regenerative medicine and disease modeling. This technology offers promising advancements in creating artificial organs and understanding disease mechanisms.

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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Three-dimensional (3D) bioprinting integrates biocompatible materials, cells, and supporting structures.
  • Stem cells, including human induced pluripotent stem cells, are revolutionizing tissue regeneration and disease modeling.
  • Reprogramming patient-specific cells enhances understanding of disease mechanisms and variability.

Purpose of the Study:

  • To review current advances in 3D bioprinting using stem cells.
  • To discuss applications, limitations, and future directions of stem cell-based 3D bioprinting.
  • To explore the use of 3D bioprinting across various organ systems.

Main Methods:

  • Review of recent literature on 3D bioprinting technologies and stem cell applications.
  • Discussion of different bioprinting techniques: microextrusion, inkjet, laser-assisted, and scaffold-free spheroid-based bioprinting.
  • Analysis of stem cell types and potencies used in bioprinting.

Main Results:

  • Successful 3D bioprinting has been achieved using diverse stem cell types.
  • Various bioprinting technologies have been employed, with scaffold-free methods emerging.
  • The potential for artificial organ printing and personalized medicine is significant.

Conclusions:

  • 3D bioprinting with stem cells is a rapidly advancing field with vast potential in regenerative medicine.
  • Continued research is needed to overcome limitations and fully realize applications in organ printing and disease study.
  • Future directions include refining techniques and expanding applications across all organ systems.