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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Updated: Feb 21, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Cancer stem cells revisited.

Eduard Batlle1,2,3, Hans Clevers4

  • 1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Nature Medicine
|October 7, 2017
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor growth but are hard to eliminate. New research using lineage-tracing and cell-ablation strategies offers insights into CSC behavior and emerging therapies.

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Last Updated: Feb 21, 2026

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Area of Science:

  • Oncology
  • Stem Cell Biology

Background:

  • The cancer stem cell (CSC) hypothesis posits that tumors are sustained by a small population of stem cells.
  • Identifying and eradicating CSCs has proven challenging despite their known presence in tumor niches.

Purpose of the Study:

  • To review recent advancements in understanding cancer stem cells.
  • To connect new CSC insights with normal stem cell biology.
  • To discuss the evolving landscape of CSC-targeted therapies.

Main Methods:

  • Lineage-tracing techniques to track cell fate and behavior.
  • Cell-ablation strategies to eliminate specific cell populations.
  • Comparative analysis of CSCs and normal stem cells.

Main Results:

  • Recent strategies have illuminated CSC plasticity, quiescence, self-renewal, and treatment responses.
  • A deeper understanding of CSCs in relation to normal stem cell maintenance is emerging.
  • Therapeutic approaches based on the CSC concept are beginning to show success.

Conclusions:

  • Expectations for CSC-targeting therapies are becoming more realistic.
  • The CSC concept continues to evolve, integrating new findings from stem cell biology.
  • Early successes indicate the therapeutic potential of targeting cancer stem cells.