Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Experimental RNAi02:15

Experimental RNAi

8.0K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated transcriptomic and metabolomic analyses reveal key regulators associated with lipid metabolic differences between subcutaneous and visceral adipose tissues in sheep.

Genomics·2026
Same author

Nanotechnology-enabled precision strategies for bladder cancer: from in vitro diagnostics to in vivo therapy.

Journal of nanobiotechnology·2026
Same author

Ultrasound-guided modified superior laryngeal nerve block for awake tracheal intubation in patients with difficult airways.

BMC anesthesiology·2026
Same author

Predicting an intrinsic conformational twist in Card1: an in silico study.

Journal of molecular modeling·2026
Same author

A cooperative effect of ligands, Mg<sup>2+</sup> ions, and the U6C mutation on the structural dynamics of the SAM-Ⅵ Riboswitch.

The Journal of biological chemistry·2026
Same author

lncRNA, miRNA, and mRNA dynamics in cholangiocyte-to-immature hepatocyte differentiation in liver regeneration.

Scientific data·2026

Related Experiment Video

Updated: Feb 21, 2026

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

8.0K

EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments.

Bailing Zhou1,2, Huiying Zhao3, Jiafeng Yu1,2

  • 1Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China.

Nucleic Acids Research
|October 7, 2017
PubMed
Summary

A new database, EVLncRNAs, now centralizes experimentally validated long non-coding RNAs (lncRNAs). This comprehensive resource aids research by consolidating structures, functions, and phenotypes for these crucial biological molecules.

More Related Videos

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.4K
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

2.7K

Related Experiment Videos

Last Updated: Feb 21, 2026

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

8.0K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.4K
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

2.7K

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of diverse biological processes.
  • Existing databases for lncRNAs are limited in scale and scope, often focusing on specific aspects like plants, diseases, or interactions.
  • There is a need for a comprehensive, centralized repository of experimentally validated lncRNAs.

Purpose of the Study:

  • To establish EVLncRNAs, a comprehensive database of experimentally validated lncRNAs.
  • To integrate data from existing lncRNA databases and supplement it with functional and disease-specific information.
  • To provide a centralized resource for the structures, functions, and phenotypes of validated lncRNAs.

Main Methods:

  • Curated lncRNAs validated by low-throughput experiments up to May 1, 2016.
  • Integrated data from lncRNAdb, LncRANDisease, Lnc2Cancer, and PLNIncRBase.
  • Added functional and disease-specific information not previously covered.

Main Results:

  • The EVLncRNAs database contains 1543 lncRNAs from 77 species.
  • It is 2.9 times larger than the largest existing database of experimentally validated lncRNAs.
  • 74% of entries are novel compared to existing validated lncRNA databases.
  • The database offers browsing, searching, downloading, and submission functionalities.

Conclusions:

  • EVLncRNAs provides a significantly expanded and integrated resource for experimentally validated lncRNAs.
  • The database facilitates research by offering a centralized repository of lncRNA data.
  • EVLncRNAs is accessible online for researchers worldwide.